The MULTI-STR3AM project is designed to overcome these barriers. It will use a three-pillar approach: improving the strains of microalgae to boost productivity; designing and engineering more cost-effective production techniques; exploiting sidestreams, biomass and upscaling production to be able to provide a realistic alternative supply. It will do this within a centralised MULTI-biorefinery, valorising all biomass fractions using a sustainable and economically viable production model. Ultimately, the MULTI-STR3AM project aims to create a roadmap for establishing economically viable microalgae production and exploration, preserving resources and contributing to the EU’s circular economy goals.